What Is Thyroid Hormone Physiology Primer?

    Many of you report to my office with a complaint of being hypothyroid only to have been advised by your primary care provider that you’re normal on testing. Guess what? They are correct! Butso are you. However, they haven’t gone far enough to record what you know to be true.

    Hormonal factor

    Your thyroid gland the majority of the time is producing sufficient amounts of thyroidgland. However, after it leaves the gland, the mind takes over and it responds to environmental cues, sleep, stress, exercise, etc.. This reaction changes the action of enzymes which control the conversion of your thyroid gland to its active form called T3. This needs to be assessed to satisfactorily determine your thyroid activity.

    I’ve included a feedback chart under the physiology. THYROID (the gland produces 4 kinds of thyroid gland, T1-4- 90 percent of output as T4, 10 percent of output as T3. T3- reverseT3. Reverse T3 isn’t able to bind the thyroid gland and functions as a “thyroid brake” restricting the metabolic effects of thyroidgland.


    The principal stress hormone that regulates all this is CRH(corticotropin releasing hormone). This is also published by the hypothalamus in the brain. It stimulates the release of ACTH(adrenocorticotropin hormone). It stimulates the adrenal gland to release adrenaline and cortisone, the principal stress hormones. When CRHis published, TRH and then TSH are reduced.

    Consider it this way. The thyroid’s most important role is to establish the metabolic rate and oxygen consumption in the body. When the thyroid is diminished, fatigue, body temperature decrease, weight control issues, constipation, hair loss, etc. . This occurs under stress because the mind believes it must prioritize fueling to provide the stress response that may entail fighting or running to escape danger.

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    Metabolic Rate

    Reducing metabolic rate by reducing thyroid activity will help the body maintain sufficient fuel to the stress response/escape. When your primary care providers evaluate your thyroid, they generally only measure TSH and possibly T4. They don’t examine the remainder of the chemistry. So, when they tell you your thyroid is producing normally, technically they’re correct, but they aren’t accounting for the environmental influences that all of us endure these days. And of course, there are micronutrient issues/deficiencies in our food supply that deny us adequate micronutrient support which supports the standard conversion of thyroid.

    Without assessing T3 and rT3 levels, there’s absolutely not any acknowledgment of surroundings / nutritional issues and the origin of hypothyroid symptoms may be missed. But, here is your KEY POINT! If your brain isn’t allowing conversion to T3 and shunting into rT3 instead, it’s doing so as reimbursement to your lifestyle and stressors in an attempt to protect you. Oftentimes, attempting to provide T3 to compensate for modified conversion won’t address the problem as the mind will see this as going against its own programming.

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    In my experience, the majority of the time, some progress in this chemistry can be found. However, you might not have the ability to attain the complete rebalancing with no homage being paid to your own phobias. Sorry, this is just the reality of how this works. This is a really intricate chemistry which needs a broader evaluation when symptoms of low activity present. An increasing number of physicians are beginning to look at this more in depth. Hopefully, this primer will educate you a bit on what you should be searching for and asking your physician about. You might not receive a positive response to your query, unfortunately. Take heart, there are more people out there that will listen.


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